Member News

Autism Genes Activate During Fetal Brain Development

Scientists at the University of California, San Diego School of Medicine have found that mutations that cause autism in children are connected to a pathway that regulates brain development. The research, led by Lilia Iakoucheva, PhD, assistant professor in the Department of Psychiatry, is published in the February 18 issue of Neuron.

The researchers studied a set of well-known autism mutations called copy number variants or CNVs. They investigated when and where the genes were expressed during brain development. "One surprising thing that we immediately observed was that different CNVs seemed to be turned on in different developmental periods," said Iakoucheva.

Specifically, the scientists noted that one CNV located in a region of the genome known as 16p11.2, contained genes active during the late mid-fetal period. Ultimately, they identified a network of genes that showed a similar pattern of activation including KCTD13 within 16p11.2 and CUL3, a gene from a different chromosome that is also mutated in children with autism.

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Freedom Meditech CEO Selected for 10.10.10 Challenge

Local San Diego entrepreneur, Craig Misrach, founder and CEO of medical device company Freedom Meditech has been named one of ten CEOs as part of 10.10.10, an initiative that challenges 10 entrepreneurs from around the United States as prospective CEOs to wrestle 10 market pain points in just ten days - ending with a few extraordinary, fundable startups.

Harnessing entrepreneurial power and speed, the selected CEOs will hear passionate pitches from Problem Advocates who highlight specific "Wicked Problems" and the CEOs decide which opportunities to pursue. The CEOs will have access to 10-20 Validators who will help them make better decisions. These Validators (corporations, nonprofits and individuals that understand the market for a solution), help CEOs gain insights into market opportunities best suited to their vision, talent, experience, ambition and capabilities. Validators bring their understanding of the need and the market opportunities in health, healthcare, digital health and wellness. They mitigate risk, identify resources and reveal substantial opportunities making them valuable to both entrepreneurs and investors.

The identified Wicked Problems:
1. Alzheimer's
2. Childhood Obesity
3. Patient Engagement
4. Antibiotic Resistance
5. End of Life Care
6. Pandemic Weapons and Bioterrorism
7. Patient and Data Matching
8. Health Guide Maps
9. Health Data
10. Patient Mobility and Independence

To learn more about this 10 day collaborative program, please visit this link: www.101010.net/

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Tau-Associated MAPT Gene Increases Risk for Alzheimer’s Disease

An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, has identified the microtubule-associated protein tau (MAPT) gene as increasing the risk for developing Alzheimer's disease (AD). The MAPT gene encodes the tau protein, which is involved with a number of neurodegenerative disorders, including Parkinson's disease (PD) and AD. These findings provide novel insight into Alzheimer's neurodegeneration, possibly opening the door for improved clinical diagnosis and treatment.

The findings are published in the February 18 online issue of Molecular Psychiatry.

Alzheimer's disease, which afflicts an estimated 5 million Americans, is typically characterized by progressive decline in cognitive skills, such as memory and language and behavioral changes. While some recent AD genome-wide association studies (GWAS), which search the entire human genome for small variations, have suggested that MAPT is associated with increased risk for AD, other studies have found no association. In comparison, a number of studies have found a strong association between MAPT and other neurodegenerative disorders, such as PD.

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Rady School of Management at UC San Diego Launches Center for Business Analytics

The Rady School of Management at UC San Diego today announced the launch of its Center for Business Analytics, which will serve as a platform for research and innovation in big data analysis for private businesses and public agencies.
Rady School also announced that Urban Insights Associates, Inc., a wholly owned subsidiary of Cubic Transportation Systems, a business segment of Cubic Corporation (NYSE:CUB), is the Center's first corporate sponsor.
In a joint statement Rady School's Professor of Marketing Karsten Hansen and Associate Professor of Marketing On Amir said, "We are privileged to welcome Urban Insights as our first corporate sponsor and partner of the newly launched Rady School Center for Business Analytics. The partnership and generous support Urban Insights is providing to the Rady School's Center for Business Analytics will enable the advancement of innovative research and increase collaboration with businesses and public agencies. Data analytics is revolutionizing the business world and the Center for Business Analytics will help prepare Rady's graduate students to become leaders in this sector."

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